L-methylfolate : CerefolinNAC®
A medical food for the dietary management of neurovascular oxidative stress and/or hyperhomocysteinemia.
L-methylfolate
L-methylfolate in CerefolinNAC® offers homocysteine protection
L-methylfolate is directly involved in Hcy metabolism.
In a comparison of single dose 5mg L-methylfolate to 5mg folic acid, L-methylfolate was 3X more effective in decreasing plasma homocysteine.
CerefolinNAC® provides your patients with the superior homocysteine effect of 5mg L-methylfolate.
Data on file
L-methylfolate in CerefolinNAC® Offers Superior Bioavailability
Data on file
- 5mg L-methylfolate is 7x more bioavailable than 5mg folic acid.
- The peak concentration (Cmax) of L-methylfolate was higher (129 ng vs 14.1 ng) after 5 mg oral dose L-methylfolate compared to 5 mg oral dose folic acid.
Folic Acid Blocks Transport of L-methylfolate Across the Blood Brain Barrier
This illustration represents technical information presented in: Wu D and Pardridge WM. Blood-brain barrier transport of reduced folic acid. Pharmaceutical Research. 1999;16(3):415-419. Spector R and Lorenzo AV. Folate transport in the central nervous system. Am J Physiol. 1975;229(3):777-82.
- L-methylfolate is 7x more bioavailable than folic acid.
- CerefolinNAC® contains the active form of folate (L-methyfolate) that crosses the blood brain barrier and is immediately used by the brain to
- reduce homocysteine and oxidative stress
- normalize acetylcholine
2 out of 3 cognitively impaired patients may have a compromised ability to get folate into the brain
Early memory loss patients have low Cerebral Spinal Fluid (CSF) levels of folate. L-methylfolate in CerefolinNAC® provides the nutritional requirements to increase folate levels in the brain.4 Patients with the MTHFR polymorphism and elevated homocysteine, particularly when associated with low serum folate levels, are 6X more likely to develop progressive memory loss.1
This illustration represents technical information presented in: Yoo J, Choi G, Kang S. Pathogenicity of Thermolabile Methylenetetrahydrofolate Reductase for Vascular Dementia. Artioscler Thromb Vasc Biol. August 2000;1921-1925.
Due to the MTHFR polymorphism, 2 out of 3 memory impaired patients have a distinct need to get L-methylfolate into the brain. 2
L-methylfolate in Cerefolin®NAC is the only form of folate used by the brain3
This chart represents technical information presented in: Refsum H, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Chemical Chemistry. 2004;50(1):3-32.
- L-methylfolate is unaffected by the CT/TT genotypes of MTHFR.
- No conversion is required with L-methylfolate.
- CerefolinNAC® contains L-methylfolate, the active form of folate, to:
- reduce homocysteine and oxidative stress
- support the synthesis of acetylcholine
- Anello G, et al. Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease. NeuroReport. 2004;15(5):859-861.
- Yoo J, Choi G, Kang S. Pathogenicity of Thermolabile Methylenetetrahydrofolate Reductase for Vascular Dementia. Artioscler Thromb Vasc Biol. August 2000;1921-1925.
- 3. Willems FF, et al. Pharmacokinetic study of the utilization of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease. Brit Jrnl of Pharmacology. 2004;151:825-830.