L-methylfolate : CerefolinNAC
A medical food for the dietary management of neurovascular oxidative stress and/or hyperhomocysteinemia.
L-methylfolate
L-METHYLFOLATE IN CEREFOLIN®NAC OFFERS SUPERIOR HOMOCYSTEINE PROTECTION
L-methylfolate is directly involved in Hcy metabolism.
In a comparison of single dose 5mg L-methylfolate to 5mg folic acid, L-methylfolate was 3X more effective in decreasing plasma homocysteine.
Cerefolin®NAC provides your patients with the superior homocysteine effect of 5mg L-methylfolate.
Data on file
L-methylfolate in Cerefolin®NAC Offers Superior Bioavailability
Data on file
- 5mg L-methylfolate is 7x more bioavailable than 5mg folic acid.
- The peak concentration (Cmax) of L-methylfolate was higher (129 ng vs 14.1 ng) after 5 mg oral dose L-methylfolate compared to 5 mg oral dose folic acid.
Folic Acid Blocks Transport of L-methylfolate Across the Blood Brain Barrier
This illustration represents technical information presented in: Wu D and Pardridge WM. Blood-brain barrier transport of reduced folic acid. Pharmaceutical Research. 1999;16(3):415-419. Spector R and Lorenzo AV. Folate transport in the central nervous system. Am J Physiol. 1975;229(3):777-82.
- L-methylfolate is 7x more bioavailable than folic acid.
- Cerefolin®NAC contains the active form of folate that crosses the blood brain barrier and is immediately used by the brain to
- reduce homocysteine and oxidative stress
- normalize acetylcholine
2 out of 3 cognitively impaired patients may have a compromised ability to get folate into the brain
Patients with the MTHFR Polymorphism and elevated homocysteine are 6X more likely to develop progressive memory loss.1
2 out of 3 memory impaired patients have a compromised ability to get folate into the brain. 2
This illustration represents technical information presented in: Yoo J, Choi G, Kang S. Pathogenicity of Thermolabile Methylenetetrahydrofolate Reductase for Vascular Dementia. Artioscler Thromb Vasc Biol. August 2000;1921-1925.
L-methylfolate in Cerefolin®NAC is the only form of folate used by the brain
This chart represents technical information presented in: Refsum H, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Chemical Chemistry. 2004;50(1):3-32.
- L-methylfolate is unaffected by the CT/TT genotypes of MTHFR.
- No conversion is required with L-methylfolate.
- Cerefolin®NAC contains L-methylfolate, the active form of folate, to:
- reduce homocysteine and oxidative stress
- support the synthesis of acetylcholine
- Anello G, et al. Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease. NeuroReport. 2004;15(5):859-861.
- Yoo J, Choi G, Kang S. Pathogenicity of Thermolabile Methylenetetrahydrofolate Reductase for Vascular Dementia. Artioscler Thromb Vasc Biol. August 2000;1921-1925.